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Laboratory of Cardiac & Aging

암 노화 연구실 (LABORATORY OF CANCER AND AGING)자료없음

Laboratory of Cancer and Aging
Our laboratory is concerned with problems in molecular biology, cell biology, oncology and medicine. Many of our studies involve studying gene functions in relation with cancer and aging to provide molecular explanation and to intercept the disease progression.
Director
  • Jeong A. Han, M.D., Ph.D.
  • Occupation :Professor
  • Title : Department of Biochemistry and Molecular Biology
  • Business Address : Kangwon National University School of Medicine, South Korea
  • Phone : +82-33-250-8832
  • E-mail : gshja@kangwon.ac.kr
Lab members
  • Ph.D. Candidates
  • 김정미
  • 김수경
  • M.S. Candidates
  • 김시훈
Selected publication
  • Lee HJ, Kim SR, Jung YJ, Han JA. Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence. Sci Rep. 2021;11(1):9853. Published 2021 May 10. doi:10.1038/s41598-021-89220-5
  • Lee HJ, Jung YJ, Lee S, Kim JI, Han JA. DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation. Mol Cells. 2020;43(4):397-407. doi:10.14348/molcells.2020.2231
  • Han JA, Kim JI. Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors. Genomics Inform. 2017;15(2):56-64. doi:10.5808/GI.2017.15.2.56
  • An HJ, Lee HJ, Jang S, et al. Transcription factor Sp1 prevents TRF2(ΔBΔM)-induced premature senescence in human diploid fibroblasts. Mol Cell Biochem. 2016;414(1-2):201-208. doi:10.1007/s11010-016-2672-7
  • Lee HJ, Kim JM, Kim KH, Heo JI, Kwak SJ, Han JA. Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53. Cell Death Differ. 2015;22(1):86-95. doi:10.1038/cdd.2014.116
  • Kim SY, Kang HT, Han JA, Park SC. The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking. Aging Cell. 2012 Dec;11(6):1102-1109.
  • Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA*. Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner. Exp Mol Med. 2012 Sep 30;44(9):536-644.
  • Choi EM, Kim SR, Lee EJ, Han JA*. Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53. Biochim Biophys Acta - Mol Cell Res. 2009, 1793(8), 1354-1365.
  • Kim SR, Park JH, Lee ME, Park JS, Park SC*, Han JA*. Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner. Mech Ageing Dev. 2008, 129(12), 706-713.
  • Lee EJ, Choi EM, Kim SR, Park JH, Kim H, Ha KS, Kim YM, Kim SS, Choi M, Kim JI, Han JA*. Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. Exp Mol Med. 2007, 39(4), 469-476.
  • Lee J, Kosaras B, Aleyasin H, Han JA, Park DS, Ratan RR, Kowell NW, Ferrante RJ, Lee SW, Rye H. Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB J. 2006, 20(13), 2375-2377.
  • Choi EM, Kwak SJ, Kim YM, Ha KS, Kim JI, Lee SW, Han JA*. COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. Exp Mol Med, 2005, 37(3), 199-203.
  • Choi EM, Heo JI, Oh JY, Kim YM, Ha KS, Kim JI, Han JA*. COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis. Biochem Biophys Res Commun. 2005, 328(4), 1107-1112.
  • Han JA, Kim JI, Ongusaha PP, Hwang DH, Ballou LR, Mahale A, Aaronson SA, Lee SW. p53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J. 2002, 21(21), 5635-5644.