Research

Laboratory of Stem Cells & Applications

LABORATORY OF STEM CELLS & APPLICATIONS

Lab Name
Laboratory of Stem Cells and Applications
Research Interest
  • Generation and applications of human pluripotent stem cell (hPSC)-derived macrophages
  • Applications of 3D alveolar organoids for respiratory disease modeling, drug testing, toxicity evaluation, and infectious study
PI and Researchers
  • PI: 홍석호, Seok-Ho Hong, Ph.D.(의학2호관 306호, , 033-250-7819)
  • 학생: 김지영 (Ji-Young Kim), 정수지 (Suji Jeong), 강민제 Minje Kang), 정지혜 (Jung Ji-Hye), 조동욱(Dong Wook Cho), 최정윤 (Jung Yun (Choi)
Research Summary

Our research topics

  • 1) hPSC-derived 3D alveolar organoids
    • serve as a powerful tool for predicting the therapeutic potential of drug candidate for pulmonary fibrosis as well as for modeling pulmonary diseases
    • provide a robust in vitro system to evaluate pulmonary toxicity of various environmental pollutants including particulate matter
    • provide in vitro platforms to predict health effect of new and variant viruses and find therapeutic approaches
  • 2) hPSC-derived functional macrophages
    • could be therapeutic target as well as therapeutic source for pulmonary fibrosis and tumor via regulation of their polarity
    • secrete extracellular vesicles transporting various biological molecules, which could be therapeutically effective for respiratory diseases