Translational Regenerative Medicine for Thoracic Cardiovascular Disease Laboratory | College of Medicine

Lab Name: Translational Regenerative Medicine for Thoracic Cardiovascular Disease Laboratory, TRM for TCD Laboratory

Research Interest

Biomaterial identification for cardiothoracic diseases (acute lung injury, chronic obstructive pulmonary disease, and pulmonary fibrosis)
Antibody and peptide-based functional enhancement technology in induced pluripotent stem cells and mesenchymal stem/stromal cells
Exosome application technology

PI and Researchers

PI : 양세란(Se-Ran Yang, D.V.M., Ph.D. 의학2호관 308호, seran@kangwon.ac.kr, 033-250-7883)
학생(한국어): 이주연, 장지민, 박재현, 차상률, 이세비, 최윤범
Students(영문): Jooyeon Lee, Jimin Jang, Jaehyun Park, Sang-Ryul Cha, Seaby Lee, Yoonbeon Lee

Research Summary: Our studies comprise the following topics: 1) To develop treatment technology for cardiothoracic disease by utilizing biomaterials, 2) Functional enhancement of iPSCs and MSCs based on treatment with antibodies or peptides, 3) To develop, analyze and apply technology of exosomes. Accordingly, our current research interests are: 1) To develop biomaterials-based therapeutic agents about various cardiothoracic diseases, such as ALI, COPD, and IPF, 2) Identifying the function of antibody/peptide-based stem cells and their exosome application to alleviate disease and enhance tissue recovery.

연구 성과 소개

Organoid Model in Idiopathic Pulmonary Fibrosis. Int J Stem Cells (2021)
WKYMVm ameliorates acute lung Injury via neutrophil antimicrobial peptide derived STAT1/IRF1 pathway. Biochem Biophys Res Commun (2020)
CMIT/MIT induce apoptosis and inflammation in alveolar epithelial cells through p38/JNK/ERK1/2 signaling pathway. Mol Cell Toxicol. (2020)
Inhibition of RAGE Attenuates Cigarette Smoke-Induced Lung Epithelial Cell Damage via RAGE-Mediated Nrf2/DAMP Signaling. Front Pharmacol. (2018)
Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling. FASEB J (2017)
Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/STAT1 pathway in mouse lung fibroblasts. Toxicol Lett (2016)
Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases. Oxid Med Cell Longev (2015)